Results 41 to 50 of about 29,135 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Numerical simulation of bearing capacity of a strip footing on strain-softening soil ground

open access: yesYantu gongcheng xuebao, 2019
To overcome the mesh sensitivity induced by strain softening, an implicit gradient plasticity model is put forward to simulate the bearing capacity of a rigid strip foundation on strain-softening soil.
LÜ Xi-lin 1, 2, XUE Da-wei 1, 2
doaj   +1 more source

The Flow Theory of Mechanism-Based Strain Gradient Plasticity

open access: yes, 2003
The flow theory of mechanism-based strain gradient (MSG) plasticity is established in this paper following the same multiscale, hierarchical framework for the deformation theory of MSG plasticity in order to connect with the Taylor model in dislocation ...
Hwang KC   +5 more
core   +1 more source

Uncoupled dissipation assumption to control elastic gaps in Gurtin-type strain gradient models [PDF]

open access: yes, 2020
Thanks to their capabilities in capturing size effects, strain gradient plasticity theories have received a strong scientific interest in the last two decades.
CAI, Lei   +2 more
core  

Line-tension model for plasticity as the Gamma-limit of a nonlinear dislocation energy [PDF]

open access: yes, 2012
In this paper we rigorously derive a line-tension model for plasticity as the Gamma-limit of a nonlinear mesoscopic dislocation energy, without resorting to the introduction of an ad hoc cut-off radius.
Scardia, L.   +4 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Grain boundary-mediated strain response mechanism of AZ31 gradient- structure Mg alloy plate under uniaxial tensile loading

open access: yesJournal of Magnesium and Alloys
The changes in strain gradient induced by grain boundaries are crucial for enhancing the plasticity of gradient magnesium (Mg) alloys. The change of strain distribution influence by grain boundaries during plastic deformation of the gradient structure ...
Wen Tao Niu   +4 more
doaj   +1 more source

Establishment of damage estimation rule for brittle fracture after cyclic plastic prestrain in steel [PDF]

open access: yesMATEC Web of Conferences, 2019
Material damage caused by complicated prestrain like cyclic prestrain and various direction prestrain. It is so important to understand the mechanism of material damage for high-precision lifetime evaluation of steel structure. Material damage depends on
Kosuge Hiroaki   +4 more
doaj   +1 more source

Strain gradient plasticity: energetic or dissipative? [PDF]

open access: yesActa Mechanica Sinica, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fleck, NA, Willis, JR
openaire   +3 more sources

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

open access: yesAdvanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez   +5 more
wiley   +1 more source

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