Results 31 to 40 of about 18,616 (264)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An investigation of dynamic mechanical behaviour of Ti6Al4V titanium alloy at room temperature
MATEC Web of Conferences, 2016 To study the high strain rate shear behaviour of Ti6Al4V titanium alloy, a series of dynamic compression experiments has been performed by split Hopkinson pressure bar (SHPB) using Flat Hat-shaped specimen at room temperature.
Ran Chun +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Jixie qiangdu, 2022 To explore the influence of external temperature and loading rate on itsrheological behavior and mechanism, the dynamic impact compression test was conducted on 022 Cr18 Ni14 Mo2 stainless steel by using the split Hopkinson compression bar test ...
JIA HaiShen +3 more
doaj
The effect of strain rate sensitivity on the prediction of the formability of advanced high strength steels [PDF]
MATEC Web of ConferencesThis paper analyzes the effect of strain rate sensitivity on the prediction of formability of advanced high-strength steels (AHSS). Three conventional dual-phase (DP) steels, 590DP, 980DP and 1180DP, and two third-generation AHSS grades with ultimate ...
Butuc Marilena C. +2 more
doaj +1 more source
International Journal of Concrete Structures and Materials, 2020 The dynamic mechanical properties of steel fiber-reinforced concrete (SFRC) under high temperature and high strain rate were studied using a split Hopkinson pressure bar (SHPB) of 74 mm in diameter.
Ruiyuan Huang +4 more
doaj +1 more source
THE MATHEMATICAL FORM OF MATERIAL CONSTITUTIVE LAWS APPLICABLE FOR MODELING OF METAL PLASTIC BEHAVIOR IN SIMULATION OF MACHINING [PDF]
مجله مدل سازی در مهندسی, 2013 Among the effects of strain hardening, strain-rate hardening, and temperature softening, it has been long argued about which effect is predominant in governing the material flow stress in machining. In addition, there is a belief that the temperature and
محمدرضا Vaziri Sereshk +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source