Results 61 to 70 of about 2,251,793 (347)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Echocardiographic Assessment of Cardiac Function by Conventional and Speckle‐Tracking Echocardiography in Dogs with Patent Ductus Arteriosus

open access: yesJournal of Veterinary Internal Medicine, 2016
Background Patent ductus arteriosus (PDA) is one of the most common congenital heart defects in dogs. Advanced echocardiographic techniques such as speckle‐tracking echocardiography (STE) have not been extensively used to evaluate cardiac function in ...
I. Spalla   +4 more
doaj   +1 more source

Leading Factors of Progression in Patients with Cardiac Amyloidosis

open access: yesРациональная фармакотерапия в кардиологии, 2022
Aim. To describe prognostic meaning of cardiac and other principal clinical manifestations of systemic AL-amyloidosis in their interrelations.Material and methods. It has been made long-time survival analysis of 147 patients with systemic AL-amyloidosis.
A. S. Rameeva   +5 more
doaj   +1 more source

Study of Uniaxial Tensile Properties of Hexagonal Boron Nitride Nanoribbons

open access: yes, 2017
Uniaxial tensile properties of hexagonal boron nitride nanoribbons and dependence of these properties on temperature, strain rate, and the inclusion of vacancy defects have been explored with molecular dynamics simulations using Tersoff potential.
Dhar, Rajkumar   +5 more
core   +1 more source

Glass dynamics at high strain rates [PDF]

open access: yesPhysical Review E, 2012
9 pages, 6 ...
Takeshi Egami, James S. Langer
openaire   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Machine for use in monitoring fatigue life for a plurality of elastomeric specimens [PDF]

open access: yes, 1977
An improved machine is described for use in determining the fatigue life for elastomeric specimens. The machine is characterized by a plurality of juxtaposed test stations, specimen support means located at each of the test stations for supporting a ...
Fitzer, G. E.
core   +1 more source

Localization in inelastic rate dependent shearing deformations

open access: yes, 2016
Metals deformed at high strain rates can exhibit failure through formation of shear bands, a phenomenon often attributed to Hadamard instability and localization of the strain into an emerging coherent structure.
Katsaounis, Theodoros   +2 more
core   +1 more source

Recent advances in echocardiography: strain and strain rate imaging [PDF]

open access: yesF1000Research, 2016
Deformation imaging by echocardiography is a well-established research tool which has been gaining interest from clinical cardiologists since the introduction of speckle tracking. Post-processing of echo images to analyze deformation has become readily available at the fingertips of the user.
Jens-Uwe Voigt   +2 more
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

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