Results 61 to 70 of about 2,821,004 (350)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

High strain rate behaviour of polypropylene microfoams

EPJ Web of Conferences, 2012
Microcellular materials such as polypropylene foams are often used in protective applications and passive safety for packaging (electronic components, aeronautical structures, food, etc.) or personal safety (helmets, knee-pads, etc.).
Martínez A.B., Arencón D., Rodríguez J., Río T. Gómez-del, Garrido M.A.   +4 more
doaj   +1 more source

Evaluation of left ventricular performance in hypertensive patients by speckle tracking echocardiography: Correlation with brain natriuretic peptide

The Egyptian Heart Journal, 2014
Background: Hypertension results in hemodynamic changes ranging from maladaptive left ventricular hypertrophy (LVH) to heart failure. Two-dimensional speckle tracking echocardiography (2D-STE) allows rapid and accurate analysis of regional and global ...
Waleed Abdou Ibrahim Hamed, Abdallah Mostafa Kamal, Mohammed Fahmy Noamany, Mahmoud Aly Soliman, Mai Mohammed Abdel Ra’ouf   +4 more
doaj   +1 more source

Properties of the strain rate sensitivity function produced by the linear viscoelasticity theory and existence of its maximum with respect to strain and strain rate

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2020
Strain rate sensitivity of stress-strain curves family generated by the Boltzmann–Volterra linear viscoelasticity constitutive equation (with an arbitrary relaxation modulus) under uni-axial loadings at constant strain rates is studied analytically as ...
Andrew Vladimirovich Khokhlov
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A material model for aluminium sheet forming at elevated temperatures [PDF]

, 2001
In order to accurately simulate the deep drawing or stretching of aluminum sheet at elevated\ud temperatures, a model is required that incorporates the temperature and strain-rate dependency of the material.\ud In this paper two models are compared: a ...
Bolt, P.J., Boogaard, A.H. van den, Werkhoven, R.J.   +2 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

STRAIN RATE EFFECT ON THE FAILURE STRAIN AND HARDNESS OF METALLIC ARMOR PLATES SUBJECTED TO HIGH VELOCITY PROJECTILE IMPACT [PDF]

Journal of Engineering Science and Technology, 2006
Post impact strain measurements of damaged plates were carried out experimentally after launching a spherical steel projectile at varying velocities against a fixed thin plate targets made of copper and steel materials and constrained at their outer ...
QASIM H. SHAH
doaj  

Revealing Microstructural Evolution and Deformation Mechanism of Pure Titanium through a Quasi In Situ Compression Method at High Strain Rate [PDF]

, 2022
Yumeng Luo, Wenqi Guo, Boya Wang, Rui Wei   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source