Results 81 to 90 of about 2,251,793 (347)

Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering [PDF]

, 2013
Background: The production of bioethanol from lignocellulose hydrolysates requires a robust, D-xylose-fermenting and inhibitor-tolerant microorganism as catalyst.
Boles, Eckhard, Bonini, Beatriz M., Demeke, Mekonnen M., Den Abt, Tom, Deprez, Sylvie, Dietz, Heiko, Dumortier, Francoise, Foulquie-Moreno, Maria R., Li, Yingying, Lidén, Gunnar,, Lund University., Mutturi, Sarma,, Thevelein, Johan M., Verplaetse, Alex   +13 more
core   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Strain-Rate Frequency Superposition in Large-Amplitude Oscillatory Shear

, 2010
In a recent work, Wyss, {\it et.al.} [Phys. Rev. Lett., {\bf 98}, 238303 (2007)] have noted a property of `soft solids' under oscillatory shear, the so-called strain-rate frequency superposition (SRFS).
A. Collyer, Ashish Lele, Chirag Kalelkar, J. Ferry, J. Kauppinen, R. Christensen, Samruddhi Kamble, W. Press   +7 more
core   +1 more source

Strain-rate amplification.

NIPPON GOMU KYOKAISHI, 1991
The strain amplification is one of the recognized causes of the reinforcement of rubber by carbon black. We evaluated strain amplification in nonequilibrium, i.e., stress-strain measurements. Carbon-black-filled rubber compounds were used. In these examples, not only strain but also strain rate is amplified, since it is a dynamic situation. Because the
openaire   +3 more sources

The Effect of Strain Rate on Diffusion Flames [PDF]

SIAM Journal on Applied Mathematics, 1975
Several steady state and time-dependent solutions to the compressible conservation laws describing direct one-step near-equilibrium irreversible exothermic burning of initially unmixed gaseous reactants, with Lewis-Semenov number unity, are presented.
Carrier, G. F., Fendell, F. E., Marble, F. E.   +2 more
openaire   +5 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Flow transitions in two-dimensional foams

, 2006
For sufficiently slow rates of strain, flowing foam can exhibit inhomogeneous flows. The nature of these flows is an area of active study in both two-dimensional model foams and three dimensional foam. Recent work in three-dimensional foam has identified
C. Macosko, Christopher Gilbreth, Michael Dennin, R. B. Bird, R. B. Bird, Scott Sullivan   +5 more
core   +1 more source

Geometrical statistics and vortex structures in helical and nonhelical turbulences [PDF]

, 2010
In this paper we conduct an analysis of the geometrical and vortical statistics in the small scales of helical and nonhelical turbulences generated with direct numerical simulations.
Gulitski G., Moffatt H. K., Moreau J. J., Yi Li   +3 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source