Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Strain rate patterns from dense GPS networks [PDF]
Natural Hazards and Earth System Sciences, 2009 The knowledge of the crustal strain rate tensor provides a description of geodynamic processes such as fault strain accumulation, which is an important parameter for seismic hazard assessment, as well as anthropogenic deformation. In the past two decades,
M. Hackl, R. Malservisi, S. Wdowinski
doaj
Investigation on Strain Rate Sensitivity of 3D Printed sPEEK-HAP/rGO Composites [PDF]
, 2021 Sagar M. Baligidad +2 more
openalex +1 more source
Strain rate effect on the mechanical behaviour of a textile reinforced cement composite [PDF]
, 2010 The static tensile behaviour of Textile Reinforced Cement Composites is known and can be modeled adequately. However, using these static material properties under dynamic loadings such as impact and seismic loadings, can cause over- or underestimation of
Blom, J +8 more
core
Strain-Rate Frequency Superposition in Large-Amplitude Oscillatory Shear
, 2010 In a recent work, Wyss, {\it et.al.} [Phys. Rev. Lett., {\bf 98}, 238303 (2007)] have noted a property of `soft solids' under oscillatory shear, the so-called strain-rate frequency superposition (SRFS).
A. Collyer +7 more
core +1 more source
Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering [PDF]
, 2013 Background: The production of bioethanol from lignocellulose hydrolysates requires a robust, D-xylose-fermenting and inhibitor-tolerant microorganism as catalyst.
Boles, Eckhard +13 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Simple and Convenient Correction of Molecular Dynamics Mechanical Property Predictions for Strain Rate, Temperature, and Degree of Cure [PDF]
, 2022 Sagar Patil +6 more
openalex +1 more source
Localization in inelastic rate dependent shearing deformations
, 2016 Metals deformed at high strain rates can exhibit failure through formation of shear bands, a phenomenon often attributed to Hadamard instability and localization of the strain into an emerging coherent structure.
Katsaounis, Theodoros +2 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source