Results 111 to 120 of about 3,946,620 (362)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Quasi-Static Loading Responses and Constitutive Modeling of Al–Si–Mg alloy

Metals, 2018
The flow behavior of the Al–Si–Mg alloy under uniaxial compression loading was investigated at different strain rates (10−3 s−1, 10−2 s−1,10−1 s−1, 100 s−1) at a wide range of temperatures (573 K, 623
Zhenglong Liang, Qi Zhang
doaj   +1 more source

A parametric metamodel of the vehicle frontal structure accounting for material properties and strain-rate effect: application to full frontal rigid barrier crash test. [PDF]

Heliyon, 2022
Pasquale A, Champaney V, Kim Y, Hascoët N, Ammar A, Chinesta F.   +5 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A new Dynamic Plasticity and Failure Model for Metals

Metals, 2019
A new plasticity and failure model is developed herein for metallic materials subjected to dynamic loadings on the basis of the analysis of some available material test data and previous work.
Lin Zhou, Heming Wen
doaj   +1 more source

Strain Rate Effect upon Mechanical Behaviour of Hydrogen-Charged Cycled NiTi Shape Memory Alloy. [PDF]

Materials (Basel), 2021
Gamaoun F.
europepmc   +1 more source

Strain-rate effect on consolidation behaviour of Ariake clay [PDF]

, 2010
A total of 114 constant rate of strain (CRS) consolidation tests and 15 incremental loading (IL) consolidation tests were conducted for undisturbed Ariake clay samples from three boreholes in the Saga Plain, Kyushu, Japan, to systematically investigate ...
Z.-S. Hong, J.-C. Chai, T. Hino, R. Jia
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Fragility Analysis of Concrete-Filled Steel Tubular Frame Structures with BRBs under Multiple Earthquakes Considering Strain Rate Effects

Applied Sciences, 2019
The fragility of concrete-filled steel tubular (CFST) frame structures with buckling-restrained braces (BRBs) subjected to multiple earthquakes is studied in this paper.
Hao Zhang, Chao Li, Si-Meng Jiang, Peng-Fei Liu, Qing-Meng Gao   +4 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source