Results 101 to 110 of about 19,178,039 (347)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Strain-Rate Selection in the Constant-Rate-of-Strain Consolidation Test [PDF]

open access: yes, 1981
Constant-rate-of-strain (CRS) consolidation tests were performed on remolded kaolinite specimens. The effect of strain rate on CRS test data is shown. A relation between soil parameters and strain rate was developed and used to formulate a strain-rate ...
Gorman, C. Thomas
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Effects of Non-Destructive Overloading on the Mechanical Properties, Microstructure and Ultrastructure of Rabbit Patellar Tendons

open access: yesJournal of Biomechanical Science and Engineering, 2009
Incomplete or subfailure injuries of tendons occur more frequently than their complete ruptures. However, the mechanical behavior of the incompletely injured tissues is poorly understood.
Ei YAMAMOTO, Kousuke OHTA
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Mechanical Behavior and Fracture Properties of NiAl Intermetallic Alloy with Different Copper Contents

open access: yesApplied Sciences, 2016
The deformation behavior and fracture characteristics of NiAl intermetallic alloy containing 5~7 at% Cu are investigated at room temperature under strain rates ranging from 1 × 10−3 to 5 × 103 s−1.
Tao-Hsing Chen, Jian-Hong Wu
doaj   +1 more source

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