Results 81 to 90 of about 3,946,620 (362)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Baozha yu ChongjiIn order to investigate the dynamic mechanical properties of ultra-high performance concrete (UHPC) under coupled high-temperature and explosive impact effects, a 75 mm-diameter high-temperature split Hopkinson pressure bar (SHPB) apparatus was employed.
Chen ZHANG +4 more
doaj +1 more source
Strain-rate sensitivity of die-cast magnesium-aluminium based alloys [PDF]
, 2017 The strain-rate effect in die-cast magnesium-aluminium based alloys under quasi-static strain rates ranging from 10-6 to 10-1 s-1 was investigated. The strain-rate sensitivity was shown to decrease with increasing aluminium solute level in the matrix ...
Suming Zhu (19551988) +4 more
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Strain Rate Effect on Transmission Tower-Line System under Earthquake [PDF]
, 2011 Using ABAQUS software, three dimensional finite element model of a transmission tower-line system is created. Nonlinear seismic responses under three seismic records with and without strain rate effect are studied.
Wen Ming Wang +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Effect of Strain Rate on Compressive Behaviour of Silicone Rubber
EPJ Web of Conferences, 2018 The purpose of this study is to evaluate the effect of strain rate on compressive behaviour of silicone rubber. The silicone rubber which was used as biomimetic material was prepared as a specimen. The shape of specimen was cubic and each side length was
Tateyama Kohei +2 more
doaj +1 more source
Determining the effect of strain rate on the fracture of sheet steel [PDF]
A key challenge for the automotive industry is to reduce vehicle mass without compromising on crash safety. To achieve this, it is necessary to model local failure in a material rather than design to the overly conservative criteria of total elongation
Beaumont, Richard Adrian
core
Strain-rate-dependent microplane model for high-rate comminution of concrete under impact based on kinetic energy release theory [PDF]
, 2015 The apparent increase of strength of concrete at very high strain rates experienced in projectile impact (10 s(-1) to 10(6) s(-1)), called 'dynamic overstress', has recently been explained by the theory of release of local kinetic energy of shear strain ...
Kirane K +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source