Results 71 to 80 of about 3,946,620 (362)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Investigation of the mechanical behavior of kangaroo humeral head cartilage tissue by a porohyperelastic model based on the strain-rate-dependent permeability [PDF]
, 2015 Solid–interstitial fluid permeability,is significant to the strain-rate-dependent mechanical behavior of humeralhead(shoulder)cartilage.Due to anatomical and biomechanical similarities to that of thehumanshoulder,kangaroos present a suitable animal ...
Thibbotuwawa, Namal +4 more
core +1 more source
Size effect on the high strain rate micro/meso-tensile behaviors of pure titanium foil
, 2021 The influence of size effect on deformation behaviors at quasi-static strain rate has been widely studied in recent years. However, there is little research about size effect on deformation behaviors of metal foils at high strain rate. To clarify how the
Cheng Zhu +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Effect of microstructure on anomalous strain-rate-dependent behaviour of bacterial cellulose hydrogel [PDF]
, 2016 This study is focused on anomalous strain-rate-dependent behaviour of bacterial cellulose (BC) hydrogel that can be strain-rate insensitive, hardening, softening, or strain-rate insensitive in various ranges of strain rate.
Andrew Ka-Chun Lau (7212893) +5 more
core +3 more sources
In vivo human cardiac shortening and lengthening velocity is region-dependent and not coupled with heart rate [PDF]
, 2015 New Findings •What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly ...
Stöhr, Eric J. +2 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Investigation of advanced strain-path dependent material models for sheet metal forming simulations [PDF]
, 2006 Sheet metal forming processes often involve complex loading sequences. To improve the prediction of some undesirable phenomena, such as springback, physical behavior models should be considered.
BALAN, Tudor +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source