Results 61 to 70 of about 1,118,595 (265)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Effects of Non-Destructive Overloading on the Mechanical Properties, Microstructure and Ultrastructure of Rabbit Patellar Tendons

open access: yesJournal of Biomechanical Science and Engineering, 2009
Incomplete or subfailure injuries of tendons occur more frequently than their complete ruptures. However, the mechanical behavior of the incompletely injured tissues is poorly understood.
Ei YAMAMOTO, Kousuke OHTA
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Mechanical Behavior and Fracture Properties of NiAl Intermetallic Alloy with Different Copper Contents

open access: yesApplied Sciences, 2016
The deformation behavior and fracture characteristics of NiAl intermetallic alloy containing 5~7 at% Cu are investigated at room temperature under strain rates ranging from 1 × 10−3 to 5 × 103 s−1.
Tao-Hsing Chen, Jian-Hong Wu
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Kinematic and isotropic strain hardening in copper with highly aligned nanoscale twins

open access: yesMaterials Research Letters, 2018
The kinematic and isotropic strain hardening was investigated in columnar-grained copper with preferentially oriented nanoscale twins deformed at two different strain rates of 5 × 10−5 and 5 × 10−3 s−1.
Hao Wang, Zesheng You, Lei Lu
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

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