Results 121 to 130 of about 19,178,039 (347)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
A new Dynamic Plasticity and Failure Model for Metals
Metals, 2019 A new plasticity and failure model is developed herein for metallic materials subjected to dynamic loadings on the basis of the analysis of some available material test data and previous work.
Lin Zhou, Heming Wen
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Strain-rate sensitivity of die-cast magnesium-aluminium based alloys
, 2017 The strain-rate effect in die-cast magnesium-aluminium based alloys under quasi-static strain rates ranging from 10-6 to 10-1 s-1 was investigated. The strain-rate sensitivity was shown to decrease with increasing aluminium solute level in the matrix ...
Suming Zhu (19551988) +4 more
core
Indentation size effect and strain rate sensitivity of nanocrystalline Mg-Al alloys [PDF]
, 2010 Deformation Behaviour of microcrystalline (mc) and nanocrystalline (nc) Mg-5%Al alloys produced by hot extrusion of ball-milled powders were investigated using instrumented indentation tests.
Zhang, Guangping +4 more
core
Ductile to brittle transition of fracture of a Zr-based bulk metallic glass: Strain rate effect
, 2016 Quasi-static and dynamic tensile experiments were conducted on a Zr-based bulk metallic glass at room temperature. A significant ductile-to-brittle transition was identified with increasing strain rate, based on the changes in the macroscopic fracture ...
Li G +6 more
core +1 more source
Applied Sciences, 2019 The fragility of concrete-filled steel tubular (CFST) frame structures with buckling-restrained braces (BRBs) subjected to multiple earthquakes is studied in this paper.
Hao Zhang +4 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source