Results 91 to 100 of about 2,896,568 (290)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Theory of strains in auxetic materials [PDF]

, 2012
Auxetic materials, or negative-Poisson's-ratio materials, are important technologically and fascinating theoretically. When loaded by external stresses, their internal strains are governed by correlated motion of internal structural degrees of freedom ...
Blumenfeld, Raphael, Edwards, Sam F.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Trypanosoma cruzi: Genomic Diversity and Structure

Pathogens
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease, and one of the most important parasitic diseases worldwide. The first genome of T.
Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Núria Gironès, Manuel Fresno   +3 more
doaj   +1 more source

Inhibition of growth and ochratoxin A production of Aspergillus carbonariu by Bacillus strains isolated from cocoa bean fermentation [PDF]

, 2019
Ivorian raw cocoa beans are recurrently subject to ochratoxin A (OTA) contamination. The use of chemical and physical means to reduce or prevent the OTA production in cocoa beans is prohibited or inefficient.
Beugre, Guézéré Corinne, Boulanger, Renaud, Durand, Noël, Fontana-Tachon, Angélique, Guehi, Tagro Simplice, Kadjo, Adobi Christian, Kedjebo, Kra Brou Didier   +6 more
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Total antibodies and neutralizing ability of convalescent sera against three different strains of SARS-CoV-2

Вопросы вирусологии
The aim of the study was to assess the level of humoral immunity to SARS-CoV-2 in COVID-19 convalescents. Materials and methods. We used ELISA for antibody quantitation, microneutralization test using three SARS-CoV-2 strains for neutralizing activity
Natalia V. Palyanova, Lubov S. Adamenko, Olga G. Kurskaya, Tereza A. Saroyan, Mariya V. Solomatina, Ivan A. Sobolev, Alexander M. Shestopalov   +6 more
doaj   +1 more source

Long-range order and short-range disorder in Saccharomyces cerevisiae biofilm

Engineering Biology, 2019
Biofilm, a colony forming cooperative response of microorganisms under environmental stress, is a major concern for food safety, water safety and drug resistance. Most current works focus on controlling biofilm growth by targeting single genes. Here, the
Vincent Piras, Adam Chiow, Kumar Selvarajoo   +2 more
doaj   +1 more source

Spatiotemporal co-existence of two Mycobacterium ulcerans clonal complexes in the Offin River Valley of Ghana [PDF]

, 2016
In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely related isolates and a striking association between ...
Aboagye, Samuel, Ampah, Kobina Assan, Asante-Poku, Adwoa, Asare, Prince, Danso, Emelia, Harris, Simon R., Kerber, Sarah, Lamelas, Araceli, Parkhill, Julian, Pluschke, Gerd, Röltgen, Katharina, Yeboah-Manu, Dorothy   +11 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source