Results 51 to 60 of about 2,896,568 (290)

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

Veterinary Research, 2021
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting several captive, free ranging and wild cervid species. Responsible for marked population declines in North America, its geographical spread is now becoming a ...
Katayoun Moazami-Goudarzi, Olivier Andréoletti, Jean-Luc Vilotte, Vincent Béringue   +3 more
doaj   +1 more source

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson’s Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

Cells, 2021
Parkinson’s disease (PD) and multiple system atrophy (MSA) are caused by two distinct strains of disease-associated α-synuclein (αSynD). Recently, we have shown that olfactory mucosa (OM) samples of patients with PD and MSA can seed the aggregation of ...
Chiara Maria Giulia De Luca, Alessandra Consonni, Federico Angelo Cazzaniga, Edoardo Bistaffa, Giuseppe Bufano, Giorgia Quitarrini, Luigi Celauro, Giuseppe Legname, Roberto Eleopra, Fulvio Baggi, Giorgio Giaccone, Fabio Moda   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Variations in type III effector repertoires do not correlate with differences in pathological phenotypes and host range observed for Xanthomonas citri pv. citri pathotypes [PDF]

, 2012
Xanthomonas citri pv. citri (Xac) is a quarantine bacterium causing Asiatic citrus canker. Strains of Xac are classified as pathogenic variants i.e.
Arlat, Mathieu, Escalon, Aline, Gagnevin, Lionel, Javegny, Stéphanie, Noel, Laurent D., Pruvost, Olivier, Vernière, Christian, Vital, Karine   +7 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Application of CF effect, IAR and RAPD methods in evaluation or competitiveness between inoculated and indigenous strains of Rhizobium leguminosarum bv. trifolii [PDF]

Ratarstvo i Povrtarstvo, 2012
The paper evaluates the competitive ability of Rhizobium leguminosarum bv trifolii strain T49B1 used as inoculant for Trifolium repens L. (Viola) and indigenous population of rhizobia from chernozem, stagnosol and humic gleysol.
Jošić Dragana, Rasulić Nataša, Kuzmanović Đorđe, Miladinović Miroslav, Stanojković Aleksandra, Pivić Radmila   +5 more
doaj   +1 more source

Shape Sensing for an UAV Composite Half-Wing: Numerical Comparison between Modal Method and Ko’s Displacement Theory

Aerospace, 2022
Shape sensing is the reconstruction of the displacement field of a structure from some discrete surface strain measurements and is a key technology for structural health monitoring. The aim of this paper is to compare two approaches to shape sensing that
Filippo Valoriani, Marco Esposito, Marco Gherlone   +2 more
doaj   +1 more source

Pilus distribution among lineages of group b streptococcus: an evolutionary and clinical perspective [PDF]

, 2014
<b>Background</b><p></p> Group B Streptococcus (GBS) is an opportunistic pathogen in both humans and bovines. Epidemiological and phylogenetic analyses have found strains belonging to certain phylogenetic lineages to be more ...
Davies, H Dele, Lacher, David W, Manning, Shannon D, Singh, Pallavi, Springman, Amber Cody, Waymire, Emily A, Wengert, Samantha L, Zadoks, Ruth N   +7 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source