Results 61 to 70 of about 1,347,908 (268)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Trypanosoma cruzi: Genomic Diversity and Structure

Pathogens
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease, and one of the most important parasitic diseases worldwide. The first genome of T.
Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Núria Gironès, Manuel Fresno   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Total antibodies and neutralizing ability of convalescent sera against three different strains of SARS-CoV-2

Вопросы вирусологии
The aim of the study was to assess the level of humoral immunity to SARS-CoV-2 in COVID-19 convalescents. Materials and methods. We used ELISA for antibody quantitation, microneutralization test using three SARS-CoV-2 strains for neutralizing activity
Natalia V. Palyanova, Lubov S. Adamenko, Olga G. Kurskaya, Tereza A. Saroyan, Mariya V. Solomatina, Ivan A. Sobolev, Alexander M. Shestopalov   +6 more
doaj   +1 more source

Long-range order and short-range disorder in Saccharomyces cerevisiae biofilm

Engineering Biology, 2019
Biofilm, a colony forming cooperative response of microorganisms under environmental stress, is a major concern for food safety, water safety and drug resistance. Most current works focus on controlling biofilm growth by targeting single genes. Here, the
Vincent Piras, Adam Chiow, Kumar Selvarajoo   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

LOAD TESTING OF THE HERCEGOVINA BRIDGE

e-Zbornik. Elektronički Zbornik Radova Građevinskog Fakulteta
The paper presents static and dynamic load testing of the Hercegovina bridge over the Neretva River. In addition to presenting the basic structural elements of the bridge, the paper briefly describes the testing method, and provides the basic ...
Mladen Kustura, Marino Jurišić, Radoslav Markić   +2 more
doaj   +1 more source

Differential Virulence of West Nile Strains for American Crows

Emerging Infectious Diseases, 2004
Crow deaths were observed after West Nile virus (WNV) was introduced into North America, and this phenomenon has subsequently been used to monitor the spread of the virus.
Aaron C. Brault, Stanley A. Langevin, Richard A. Bowen, Nicholas A. Panella, Brad J. Biggerstaff, Barry R. Miller, Nicholas Komar   +6 more
doaj   +1 more source