Results 41 to 50 of about 1,652,994 (296)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Relations with Russia in The Context of Turkey’s Policy in Constructing its ‘Strategic Autonomy’

Uluslararası İlişkiler Dergisi, 2023
In the past two decades, the Turkish government has been seeking strategic autonomy in international relations by trying different foreign policy styles. Throughout that time, Turkey strongly prioritized its own interests in relations with other regional
Orxan Gafarli, Julia Roknifard
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The EU’s Strategic Autonomy and Good Artificial Intelligence [PDF]

Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat
IntroductionArtificial intelligence (AI) can be considered one of the key indicators and outcomes of the Fifth Industrial Revolution. This transformation has led many countries to consider adopting appropriate strategies to manage its consequences.
Mostafa Kaka, Mokhtar Salehi
doaj   +1 more source

Conceptualizing European Strategic Autonomy

Rocznik Integracji Europejskiej, 2023
Since the Global Strategy of 2016 which presented European Strategic Autonomy (ESA) a global “ambition” of the European Union, the concept of ESA became increasingly embedded in the EU policymaking. However, its meaning remains elusive due to a plurality of competing definitions and interpretations.
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

EU Open Strategic Autonomy and the Trappings of Geoeconomics

European Foreign Affairs Review, 2022
The EU’s new trade strategy promises to advance open strategic autonomy that is to balance the benefits of economic interdependence with growing demands to manage Europe’s exposure to the risks it entails. What explains these shifting priorities?
T. Gehrke
semanticscholar   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

From Quasi-Sovereignty to Full Sovereignty? The Interpretations of Strategic Autonomy and Sovereignty in the European Union

Anali Hrvatskog Politološkog Društva
The concept of European sovereignty has been in the focus of attention since Emmanuel Macron's speech at Sorbonne in 2017. Our multidisciplinary research provides a chronological overview of the efforts to establish EU strategic autonomy and sovereignty.
Anna Molnár, Éva Jakusné Harnos
doaj   +1 more source

India’s Strategic Autonomy and the US-India Strategic Partnership: Implications on Pakistan

Journal of Security & Strategic Analyses
The paper examines Indo-US strategic partnership through a structural realist lens, and analyses how India’s long-standing policy of non-alignment has always had some inclination.
Maheen Shafeeq
semanticscholar   +1 more source