Results 61 to 70 of about 1,652,994 (296)

Modi’s US Foreign Policy: Strategic Autonomy Redefined

Journal of Asian and African Studies, 2023
Since Narendra Modi came to power, there has been an upswing in the strategic ties between India and the United States. Historically, non-alignment and, later, strategic autonomy in India’s foreign policy discourse have been defined in opposition to the ...
Imran Khurshid
semanticscholar   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Digital Strategic Autonomy in South Asia: Artificial Intelligence and Cyberspace

Journal of Security & Strategic Analyses
The advent of AI and the development of cyberspace have considerably reshaped the strategic landscape of various regions, particularly South Asia, where geo-political tensions and security concerns intersect with continuous technological advancements ...
Summar Iqbal, Syeda Tabeer
semanticscholar   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

PAKISTAN'S QUEST FOR STRATEGIC AUTONOMY: HEDGING AGAINST US-CHINA-RUSSIA RIVALRIES POST2013

Pakistan journal of international affairs
Hedging has emerged as a critical element of Pakistan's foreign policy in navigating the rivalries between the US, China, and Russia post-2013. Faced with a complex geopolitical landscape, Pakistan has sought to balance and diversify its relations with ...
Mr. Nosherwan Adil, Dr. Muhammad Saeed Uzzaman ,Ms. Noor-e-Hera
semanticscholar   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Strategic autonomy: A ‘quantum leap forward on’ European total defence?

European Journal of International Security
In the last decade, the idea of total defence – a whole-of-society approach integrating civilian and military capabilities – has gained renewed prominence in Europe, including within the European Union (EU).
Jana Wrange
doaj   +1 more source

CFSP and the EU’s Strategic Autonomy: Between Ambition and Reality Amid Global Instability [PDF]

Međunarodna politika
The article explores the development, challenges, and future prospects of the European Union’s Common Foreign and Security Policy (CFSP) in light of the evolving concept of EU strategic autonomy.
Marko Novaković, Mihajlo Vučić
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source