Results 91 to 100 of about 2,765 (281)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Pragmatic Comportment Compass: Rethinking projectification in public sector projects
Project Leadership and SocietyThis study explores the relationship between public sector project managers and their organizations' formal project management processes. Utilizing Heidegger's concept of ‘practical comportment,’ we develop the ‘Pragmatic Comportment Compass,’ which ...
Kevan M. Rowe +2 more
doaj +1 more source
Strategic Compass of the EU and the Visegrad countries: a comparative analysis
Journal of Contemporary Central and Eastern EuropeThis paper examines the role of the Visegrad Group (V4) countries – the Czech Republic, Hungary, Poland and Slovakia – in shaping the EU’s Strategic Compass for security and defence. It examines the V4’s alignment on defence priorities and reveals divergent national positions on strategic autonomy and definitions of the security environment.
Timotej Kováčik, Petr Kaniok
openaire +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
NEW EU DEFENCE STRATEGY STRATEGIC COMPASS AS A RESPONSE TO MODERN HYBRID THREATS
, 2022 Olha Ivasechko, Oleh Tsebenko
openalex +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Antropologia e TeatroSince ancient times, Italy has served as a cultural bridge between Europe and Africa, generating commercial exchanges and cultural relations that have profoundly shaped both continents.
Valeria Marcolin
doaj +1 more source