Results 61 to 70 of about 2,765 (281)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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PRIORITĂȚILE POLITICO-STRATEGICE ALE UE ÎN CONTEXTUL RĂZBOIULUI DIN UCRAINA [PDF]
Revista de Știinţe Politice şi Relaţii InternaţionaleThe war in Ukraine has multiple and significant consequences for the European security architecture, and at the EU level it has caused the worst post-Cold War security crisis.
CINCĂ, SANDA
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Entrepreneurship and Sustainability IssuesThis article examines the evolving nature of the European Union's (EU) security identity, arguing that the traditional perception of the EU as a normative or civilian power is being gradually redefined in light of recent geopolitical challenges.
Radoslav Ivančík, Vladimír Andrassy
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Strategic orientations and digital marketing tactics in the international business performance of developed and emerging companies [PDF]
کاوشهای مدیریت بازرگانیEXTENDED ABSTRACT IntroductionIn today's fast-paced and hyper-competitive business environment, characterized by unprecedented technological advancements and widespread accessibility to the internet, companies are confronted with a paramount challenge ...
Hassanali Salmanian, Naser Yazdani
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Annals: Series on Military SciencesThe White Paper for European Defence and the “ReArm Europe – Readiness 2030” re-armament plan represent two key instruments designed to reinforce the European Union’s security and defence posture in an increasingly volatile strategic environment.
Major (ret.) Sînziana IANCU, Ph.D
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Institutionalization of the development management system in Poland
Management, 2018 Institutionalization of the development management system in Poland The Polish development policy was shaped along with the process of political transformation and integration with the European Union.
Sługocki Waldemar
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Frontiers in Built Environment, 2020 PurposeThis article presents a recent research and development experiment on benefits analysis for adopting building information modeling/management (BIM) systems in megaproject delivery across work stages with regard to the needs of project stakeholders.
Zhen Chen, Andrew Agapiou, Heng Li
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