Advanced Science, EarlyView.Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
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Replication of Strategic and Interactive Writing Instruction in a Nationwide Randomized Controlled Trial. [PDF]
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Accredited Continuing Medical Education Delivers: Evidence of Value, Trust, and Impact Across the Healthcare System. [PDF]
J CMEMcMahon GT.
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