Results 121 to 130 of about 268,044 (293)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Variable Sociability in Agent-Based Decision Making

open access: yes, 1999
Multi-agent system research is concerned with the issues surrounding the performance of collections of interacting agents. A major concern, therefore, is with the design of the decision making mechanism that the individual agents employ in order to ...
Jennings, N. R.   +5 more
core   +1 more source

Strategic decision -making processes : the role of information [PDF]

open access: yes, 2009
The focus of this dissertation is on the use of information in the strategic decision-making process by executives in industrial organisations and how these processes have changed in recent years e.g. under the influence of increased availability of information resources.
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The use of decision support systems in making strategic decisions in local authorities : a comparative study of Egypt and the UK

open access: yes
The application of a modified Technology Acceptance Model (TAM) to determine the factors affecting the use of Decision Support Systems (DSS) in strategic decisionmaking in local authorities in both the UK and Egypt was the main core of this research ...
Elbeltagi, Ibrahim M.
core  

Strategic Decision Making with Corporate Emotional Intelligence [PDF]

open access: yesProblems and Perspectives in Management, 2005
E. Wallace, R. Rijamampianina
doaj  

Integrating Analytical Techniques with Business Strategic Decision-Making

open access: yesEkonomika, 2004
The paper offers a discussion about the impact of strategic position on strategic decision-making. Many transitional countries are solving the problem of criteria, their selection and evaluation for a successful competition in the global environment. The
Marija Kučinskienė   +1 more
doaj  

Can We Use Routine Data for Strategic Decision Making? A Time Trend Comparison Between Survey and Routine Data in Mali. [PDF]

open access: yesGlob Health Sci Pract, 2021
Sawadogo-Lewis T   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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