Results 151 to 160 of about 6,693,188 (270)

The role of dorsomedial striatum and parvalbumin interneurons in schizophrenia-related cognitive deficits: insights from disrupted strategic decision-making in Akt1 heterozygous mice. [PDF]

Transl Psychiatry
Chang CY, Chen C, Liu YW, Gau SS, Pan YL, Lai WS.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Damage control strategy involving early strategic decision-making and staged surgical management in a hybrid emergency room system: A case report. [PDF]

Medicine (Baltimore)
Tokumaru T, Okabayashi T, Saisaka Y, Kurata H, Hata M, Tomioka J.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Application of the Analytical Hierarchy Process in the management of private ambulance care systems in three selected European countries: a strategic decision-making framework. [PDF]

Front Public Health
Rezaei J, Azouji R, Azouji M, Ghorbani H.   +3 more
europepmc   +1 more source

Correction to 'Strategic decision making about travel during disease outbreaks: a game theoretical approach'. [PDF]

J R Soc Interface, 2019
Zhao S, Bauch CT, He D.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Modelo de gestión estratégica para la toma de decisiones en entidades agropecuarias. Implementación en una UBPC del municipio Martí (Parte I)¹

Pastos y Forrajes
Este trabajo tuvo como objetivo la implementación de un modelo de gestión estratégica apropiado para apoyar la toma de decisiones en una unidad básica de producción cooperativa (UBPC) del municipio Martí (en la provincia de Matanzas, Cuba ...
Maybe Campos, J Suárez, R Ojeda
doaj  

Trait reward sensitivity modulates connectivity with the temporoparietal junction and Anterior Insula during strategic decision making. [PDF]

Biol Psychol
Sazhin D, Wyngaarden JB, Dennison JB, Zaff O, Fareri D, McCloskey MS, Alloy LB, Jarcho JM, Smith DV.   +8 more
europepmc   +1 more source

Strategic decision making about travel during disease outbreaks: a game theoretical approach. [PDF]

J R Soc Interface, 2018
Zhao S, Bauch CT, He D.
europepmc   +1 more source