Results 161 to 170 of about 196,497 (294)

The role of dorsomedial striatum and parvalbumin interneurons in schizophrenia-related cognitive deficits: insights from disrupted strategic decision-making in Akt1 heterozygous mice. [PDF]

Transl Psychiatry
Chang CY, Chen C, Liu YW, Gau SS, Pan YL, Lai WS.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modeling Supreme Court Strategic Decision Making: Congressional Constraint [PDF]

This paper addresses the contradictory results obtained in Segal (1997) and Spiller and Gely (1992) concerning the impact of institutional constraints on the US Supreme Court decisionmaking. by adapting the Spiller and Gely model to the data set utilized
Mario Bergara, Pablo T. Spiller, Barak Richman   +2 more
core  

Damage control strategy involving early strategic decision-making and staged surgical management in a hybrid emergency room system: A case report. [PDF]

Medicine (Baltimore)
Tokumaru T, Okabayashi T, Saisaka Y, Kurata H, Hata M, Tomioka J.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mental Frames and Organizational Decision-making: Facing the Challenges of Change

Adjusting to the strategic, business and economic changes requires efficient decision-making procedures which can in turn be highly affected by the underlying mental frames that the leaders of the organization hold.
Lamprinakis, Lampros, Fulton, Murray E.
core  

Enhancing strategic decision-making in differential games through bifurcation prediction. [PDF]

Sci Rep
García Pérez J, Epureanu B.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Application of the Analytical Hierarchy Process in the management of private ambulance care systems in three selected European countries: a strategic decision-making framework. [PDF]

Front Public Health
Rezaei J, Azouji R, Azouji M, Ghorbani H.   +3 more
europepmc   +1 more source

Correction to 'Strategic decision making about travel during disease outbreaks: a game theoretical approach'. [PDF]

J R Soc Interface, 2019
Zhao S, Bauch CT, He D.
europepmc   +1 more source