Results 51 to 60 of about 124,177 (299)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
BMJ Global Health, 2019 Introduction The development and implementation of national strategic plans is a critical component towards successfully addressing antimicrobial resistance (AMR).
Andrew J M Leather +19 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Managerial rationales for investing and divesting under uncertainty
Cogent Business & Management, 2019 This study examines the strategic investment and divestment decisions of fifteen Norwegian power companies that were made in response to an increasingly uncertain business environment.
Rikke S. Platou, Arild Aspelund
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The dimensions, development, and deployment of strategic leader capability [PDF]
, 2007 This research – which was motivated by a perceived gap between the reality of the world of the strategic leader and leadership development practice - offers an integrated perspective on the dimensions, development, and deployment of strategic leader ...
Laljani, Narendra
core
LONG-TERM PLANNING FOR PUBLIC INFRASTRUCTURE DEVELOPMENT AS A PRIORITY OF PUBLIC ADMINISTRATION
RUDN Journal of Public Administration, 2017 This paper presents an analysis of current state and perspectives for infrastructure deve-lopment as in the context of existing strategic planning and implementation of projects on the principles of public-private partnerships.
Alexei M Konovalov
doaj +1 more source
Defense cooperation between Serbia and Turkey as an indicator of the implementation of Davutoglu’s “Strategic Depth” [PDF]
Војно дело, 2016 The paper analyzes the level of compatibility of the defense cooperation between Serbia and Turkey from 2004 to 2014 with the concept of Ahmet Davutoglu’s foreign policy presented in his book “Strategic Depth”.
Pavlović Đorđe M.
doaj +1 more source