Announcement of the Diagnostics 2016 Junior Scientists Travel Award
With the goal of recognizing outstanding contributions to the field of medical diagnostics by early-career investigators, including assistant professors, postdoctoral students and PhD students, and assisting them in attending international conferences in ...
Diagnostics Editorial Office
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
METHODOLOGICAL GROUNDS ABOUT ALGORITHM OF DEVELOPMENT ORGANIZATIONAL ANALYSIS OF RAILWAYS OPERATION
It was established that the initial stage of reorganization is to run diagnostics of the enterprise, under which a decision on development of an algorithm for structural transformations shall be made.
H. D. Eitutis
doaj
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Financial Analysis as a Functional Subsystem of Financial Controlling [PDF]
Today’s economic situation requires enterprises to adapt to rapidly changing conditions and a strategic vision of development. In this regard, financial controlling is increasingly considered not only as a tool for controlling costs or budget execution ...
Nataliia Vyhovska +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Cost-effectiveness and alternatives to the B-1 strategic bomber / Ron Huisken.
Includes bibliographical references.On 30 June 1977, President Carter announced that the United States would not proceed with production and deployment of the B-l strategic bomber.
Huisken, Ronald Herman
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Integrated strategic supply chain positioning for SMEs: an empirical study [PDF]
Purpose - This paper reports on an investigation into the selection and evaluation of a suitable strategic positioning methodology for SMEs in Singapore.
Lim, Roland Y. G. +6 more
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Tau biology, biomarkers, and therapeutics
As Alzheimer's disease (AD) research advances, tau has emerged as both a critical biomarker and a promising therapeutic target, central to understanding disease mechanisms, tracking progression, and guiding treatment development.
Bess Frost +24 more
doaj +1 more source

