Results 81 to 90 of about 16,976,613 (392)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

METHODOLOGICAL APPROACH TO THE FORMATION OF STRATEGIC PROGRAMS OF DEVELOPMENT OF MINERAL DEPOSITS OF LOCAL IMPORTANCE

Вестник Северо-Кавказского федерального университета, 2022
It defines three groups of parameters that must be considered in the development of strategic programs of development ofmineral resources complex of local importance.
lexey Cherepovitsyn, Galina Peshkova
doaj  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Strategic prospective in knowledgemanagement: A proposal for research groups in Colombia

Revista Investigación & Desarrollo, 2013
Este artículo de reflexión trata de relacionar los conceptos de prospec- tiva, con la gestión estratégica del conocimiento, y su papel dentro de los grupos de investigación (GRIN) de las universidades colombianas.
Leonardo Pineda Serna
doaj  

Boards' strategic involvement models: Past, present, and future [PDF]

Strategic Management
Background: The research on boards' strategic involvement has increased dramatically in the last few decades due to the need for improving boards' strategic effectiveness as a mechanism for improving organizational performance.
Bozhinovska Tihona, Eftimov Ljupcho
doaj   +1 more source

Nonprofit Organizations Improving Public Relations through an Analysis of Public Perceptions [PDF]

, 2013
Hilltop Neighborhood Child Care Center is a critical support system for low-income families. The internal perceptions and the external perceptions need to be identified to better serve the organization and the community (its publics).
Carnegie, Kennan, McClain, Kayla, Naughton, Keely   +2 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Organising FDI promotion in Central-Eastern European regions [PDF]

, 2007
Increasing contest for lucrative foreign direct investment (FDI) projects requires national and, more importantly, regional authorities to actively compete and promote their areas.
Capik, Paweł
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source