Results 51 to 60 of about 13,620 (256)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Pharmaceutical companies’ views on a health technology assessment (HTA) entity in Saudi Arabia
Saudi Pharmaceutical Journal, 2020 Saudi Arabia is undergoing a massive healthcare transformation to fulfill its new, national “Vision 2030.” To align with this objective, Saudi Arabia is establishing a new, independent and evidence-based health technology assessment (HTA) entity to help ...
Hussain Abdulrahman Al-Omar +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Strategic purchasing for health: conceptual and implementation challenges in low- and middle-income countries [PDF]
, 2019 Introduction: Strategic purchasing has emerged as a key global health financing tool becoming deeply embedded into the global health policy lexicon. It has been touted as a key mechanism to deliver progress on universal health coverage (UHC).
Brown, Garrett +3 more
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Status of Quality in Strategic Purchasing in the Health System: A Systematic Review
Revista del Cuerpo Médico del HNAAA, 2020 Introducction. Strategic purchasing is an important component of financing in the health system. It can enhance productivity, justice, and accountability in the health care delivery in case of considering the quality. This study, which was conducted as a systematic review, was aimed at investigating the status of quality in five domains of strategic ...
Zarei, Zahra +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Cost Effectiveness and Resource Allocation, 2021 Background Inappropriate ways of health services purchasing for cancer patients can be challengeable and costly and seriously affect the access to health services and outcomes.
Samereh Yaghoubian +3 more
doaj +1 more source
Health needs assessment in the contemporary NHS [PDF]
, 1995 Working for Patients, published in January 1989 and the subsequent NHS and Community Care Act 1990, Introduced the most major and complex reorganisation of the NHS since its inception.
Crowe, Patricia Ann
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