Results 191 to 200 of about 64,109 (249)

Public Health Responsible AI Capability (PH-RAIC) Framework: A Conceptual Model for Integrating AI into Public Health Agencies. [PDF]

Healthcare (Basel)
Zahid A, Sharma R, Ahmed R.
europepmc   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Sustaining non-profit organizations: Strategic, managerial and financial perspectives. [PDF]

PLoS One
Harb Y, Khabbaz L, Azouri M, Estephan S.
europepmc   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Barriers and opportunities for clinical trials in Bahrain: a qualitative study of key opinion leaders. [PDF]

BMJ Open
Esther A, AlHafnawi H, Hany Shehata M, Ahmed J, Rizk D.   +4 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Digitalization and organizational capabilities: a mechanism-based integrative review. [PDF]

Front Psychol
Jia S, Khaw KW, Zhou Y.
europepmc   +1 more source

Strategic Amyotrophic Lateral Sclerosis Australia-Systems Genomics Consortium (SALSA-SGC): cohort profile. [PDF]

BMJ Open
Henders AK, Ziser L, Garton FC, Adams L, Ernst K, Furlong S, Heads JA, Heggie S, Krasniqi R, Bhadravathi Lokeshappa M, Mazumder S, McNamara E, MacShane A, Mekhael L, Nunn L, Orden B, Ryder J, Thorpe K, Toubia M, Wallace LM, Wickremeratne D, Windebank E, Benyamin B, Ngo S, Nicholson G, Pamphlett R, Steyn FJ, Visscher PM, Willams KL, Henderson R, Kiernan MC, Laing N, Mathers S, McCombe PA, Needham M, Rowe D, Schultz D, Talman P, Vucic S, Blair IP, McRae AF, Wray NR.   +41 more
europepmc   +1 more source