Results 101 to 110 of about 2,216,797 (273)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Benchmark of the Oxford Nanopore, EM-seq, and HumanMethylationEPIC BeadChip for the detection of the 5mC sites in cancer and normal samples

Frontiers in Epigenetics and Epigenomics
Introduction: Whole-genome DNA methylation identification is crucial for profiling physiologically and clinically relevant epigenetic changes. Although there are multiple experimental methods, their accuracy, advantages, and disadvantages need to be ...
Kseniia A. Deinichenko, Valentina G. Vynogradskaya, Pavel A. Grebnev, Valeriya M. Mikova, Dmitriy O. Bobylev, Abusaid M. Shaymardanov, Alexey A. Ivashechkin, Marina V. Erokhina, Alexandra I. Akinshina, Anna V. Semyanihina, Anna V. Semyanihina, Sergey I. Mitrofanov, Konstantin S. Grammatikati, Vladimir S. Yudin, Sergey M. Yudin, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Anna S. Makarova, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova   +21 more
doaj   +1 more source

THE FIRM’S PATRIMONY – AN INTERNATIONAL APPROACH [PDF]

The organization environment is characterized by uncertainty and risk that have an important impact of strategic management. In order to face this problem the managers need to plan their strategies. A useful tool in strategic planning is forecasting, but
Elena DOVAL
core  

Managing In Knowledge-Based Economies: Managing for Knowledge, Absorptive Capacity and Innovation [PDF]

, 2002
Management processes have evolved to meet changing internal and external environments through different organisational forms, systems and processes. The emerging phenomena of the knowledge based economy challenges not only the strategic management of a ...
Matthews, Judy
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Marsh migration and beyond: A scalable framework to assess tidal wetland resilience and support strategic management. [PDF]

PLoS One, 2023
Stevens RA, Shull S, Carter J, Bishop E, Herold N, Riley CA, Wasson K.   +6 more
europepmc   +1 more source

The Human Resources Strategic Management [PDF]

The most of the specialists value the role of the strategies and the tactics in modern societies development, including in the economic field, especially in increasing the companies effectiveness, but also for mezo, macro and worldwide economic levels ...
Emil SURLARU
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

URBAN MANAGEMENT– CURRENT STRATEGIC APPROACHES [PDF]

In recent years urban management conceptual evolutions are more and more connected to the chances in public administration practice, in particular to ways of raising efficiency and effectiveness.
Razvan-Andrei CORBOs, Ruxandra-Irina POPESCU   +1 more
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