Results 101 to 110 of about 10,433,910 (363)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Triple Combinations of AAV9-Vectors Encoding Anti-HIV bNAbs Provide Long-Term In Vivo Expression of Human IgG Effectively Neutralizing Pseudoviruses from HIV-1 Global Panel

Viruses
Anti-human immunodeficiency virus (HIV) broadly neutralizing antibodies (bNAbs) offer a promising approach for the treatment of HIV-1. The current paradigm for antibody therapy involves passive antibody transfer, requiring regular delivery of bNAbs in ...
German A. Shipulin, Dina V. Glazkova, Felix A. Urusov, Boris V. Belugin, Valeriya Dontsova, Alexandra V. Panova, Alyona A. Borisova, Galina M. Tsyganova, Elena V. Bogoslovskaya   +8 more
doaj   +1 more source

The Human Resources Strategic Management [PDF]

The most of the specialists value the role of the strategies and the tactics in modern societies development, including in the economic field, especially in increasing the companies effectiveness, but also for mezo, macro and worldwide economic levels ...
Emil SURLARU
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Managing In Knowledge-Based Economies: Managing for Knowledge, Absorptive Capacity and Innovation [PDF]

, 2002
Management processes have evolved to meet changing internal and external environments through different organisational forms, systems and processes. The emerging phenomena of the knowledge based economy challenges not only the strategic management of a ...
Matthews, Judy
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Benchmark of the Oxford Nanopore, EM-seq, and HumanMethylationEPIC BeadChip for the detection of the 5mC sites in cancer and normal samples

Frontiers in Epigenetics and Epigenomics
Introduction: Whole-genome DNA methylation identification is crucial for profiling physiologically and clinically relevant epigenetic changes. Although there are multiple experimental methods, their accuracy, advantages, and disadvantages need to be ...
Kseniia A. Deinichenko, Valentina G. Vynogradskaya, Pavel A. Grebnev, Valeriya M. Mikova, Dmitriy O. Bobylev, Abusaid M. Shaymardanov, Alexey A. Ivashechkin, Marina V. Erokhina, Alexandra I. Akinshina, Anna V. Semyanihina, Anna V. Semyanihina, Sergey I. Mitrofanov, Konstantin S. Grammatikati, Vladimir S. Yudin, Sergey M. Yudin, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Anna S. Makarova, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova   +21 more
doaj   +1 more source

Project Portfolio Management Capabilities of Strategic Initiatives and PMO Practices In Strategy Implementation: A Perspective of Dynamic Capability in Banking Industries in Indonesia [PDF]

, 2017
Mohammad Ichsan, Bahtiar Saleh Abbas, Mohammad Hamsal, Jimmy Sadeli   +3 more
openalex   +1 more source

A Comparative Study: Application of Strategic Operations Management Decisions in Automotive Industry Pioneers [PDF]

, 2023
Sayidatul Siti, Khazalle Durrah, Norehan Haron   +2 more
openalex   +1 more source