Results 81 to 90 of about 480,923 (314)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The effects of organizational politics and strategic posture on innovation performance

open access: yes, 2009
Strategic posture is crucial to family-owned businesses for survival. In this study, we investigate the effects of organizational politics and strategic posture (as measured by the Miles-Snow strategic typology of prospectors, analyzers, defenders, and
Özgener, Şevki   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Cross Cultural & Strategic Management

open access: yes, 2018
Cross Cultural & Strategic Management (CCSM), is dedicated to providing a forum for the publication of high quality cross-cultural and strategic management research in the global context.
Cedrola E.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ONLINE REVIEWS CAN TELL US HOW THE EXPERIENCE OF THE GUEST WITH THE VIETNAMESE HOTEL [PDF]

open access: yesGeo Journal of Tourism and Geosites
Online booking systems have transformed the travel industry by creating vast information platforms. These platforms enable customers to share their experiences, significantly influencing the destination choices of others.
Quyet Dinh PHAN   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Strategic management of outsourcing [PDF]

open access: yes, 2014
The monograph deals with outsourcing from the point of view of Slovenian enterprises, which accept outsourced activities from strong foreign enterprises. Three research activities - pilot, quantitative and central qualitative - have revealed that Slovenian enterprises frequently enter outsourcing relationships without adequate strategic, long-term ...
openaire   +1 more source

Structure and Trend Analysis of Strategic Management Subject Networks in Iran (Case Study: Strategic Management Journals)

open access: yes, 2019
Investigation of the number and diversity of articles in the field of strategic management in recent years shows that this field is one of the most favorite and well-considered areas.
Amirhossein Tayebi Abolhasani   +1 more
core  

Home - About - Disclaimer - Privacy