Results 61 to 70 of about 480,923 (314)

KEY ASPECTS OF MANAGING AN INNOVATION PROJECT IN THE EU FRAMEWORK PROGRAMME HORIZON 2020 [PDF]

Journal of Process Management and New Technologies, 2015
The program EU Horizon 2020 (ec.europa.eu) is the largest source of resources for all legal entities from Europe, with the budget of 80 billion €. It is possible to use donations from the EU for various proposals and themes, from the 91 calls for ...
Siniša M. Arsić, Miloš Ž. Arsić, Radoljub P. Tomić, Milun M. Kokanović, Marko M. Mihić   +4 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Recensione I Strategic Management Journal

, 2014
Recensione I Strategic Management ...
THOMA, Grid
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Search for signals of positive selection of circadian rhythm genes PER1, PER2, PER3 in different human populations

Вавиловский журнал генетики и селекции
The diversity of geographically distributed human populations shows considerable variation in external and internal traits of individuals. Such differences are largely attributed to genetic adaptation to various environmental influences, which include ...
A. I. Mishina, S. Y. Bakoev, A. Y. Oorzhak, A. A. Keskinov, Sh. Sh. Kabieva, A. V. Korobeinikova, V. S. Yudin, M. M. Bobrova, D. A. Shestakov, V. V. Makarov, L. V. Getmantseva   +10 more
doaj   +1 more source

Designing a Multi-Level Governance Model in Complex Organizations Based on Grounded Theory and Meta-Synthesis [PDF]

حکمرانی و توسعه
Objective: Multilevel governance is essential for achieving the vision and goals of today’s complex organizations. Therefore, the aim of this research is to present a multilevel governance model for complex organizations using a meta-synthesis of ...
Bahman Ebrahimian, ALI Taheri, Seyed abed Rezaee, Mohsen Miri, MohammadMahdi Mohtadi   +4 more
doaj   +1 more source

Strategic Entrepreneurship and Value Creation: A Comparative Case Study

, 2011
[[abstract]]This paper examines the relationship between strategic management and entrepreneurship and develops insights that advance the boundaries of the two fields and addresses an alternative strategic entrepreneurship framework.
Yee-Yeen Chu; Shih-Chang Hung　
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Final report and recommendations of the SWMG policy work group

, 1992
submitted to: the Strategic Water Management Group.Title from PDF cover (viewed on March 21, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source