Assessing inclusion of trans people in HIV national strategic plans: a review of 60 high HIV prevalence countries. [PDF]
J Int AIDS Soc, 2021 Sherwood J +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Where are the children in national hepatitis C policies? A global review of national strategic plans and guidelines. [PDF]
JHEP Rep, 2021 Malik F +6 more
europepmc +1 more source
Developing the Heritage Destination: An investigation of the implementation of strategic plans [PDF]
, 2013 This paper attempts to investigate the factors which are influential in the effective implementation of strategic planning in a heritage tourism setting. In particular, the paper looks at the respective roles of the public and private sectors in relation
Gilmore, Audrey +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
LEF2 - A strategic freight transport model for Great Britain. [PDF]
, 2005 INTRODUCTION This paper reports some innovative model building that yields a useful addition to models of freight in Great Britain. Currently, the Great Britain Freight Model (GBFM) is part of the Department for Transport's (DtT) national model suite ...
Fowkes, A.S. +2 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Lofty goals and strategic plans are not enough to achieve and maintain a diverse workforce: an American Association for the Surgery of Trauma Diversity, Equity, and Inclusion Committee conversation. [PDF]
Trauma Surg Acute Care Open, 2021 Brasel K +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source