Results 121 to 130 of about 2,195,724 (296)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Industrial production and temporary development after the Emilian Earthquake.
Italian Journal of Planning Practice, 2014 The earthquake that on the 20th of May hit Emilia has not been one of the most disastrous in modern Italian history, but it has highlighted the problem of preservation of industrial activities during a reconstruction process.
Matteo Scamporrino
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2011 In an increasingly competitive business environment, many organizations have adopted the strategic planning approach in an attempt to achieve excellence in business.
Dodangeh, Javad +5 more
core
The Role of Knowledge in the prevention of natural hazards and related risks.
Italian Journal of Planning Practice, 2014 Human activities, especially over the last two centuries, have had a huge impact on the environment and the landscape. Mankind is able to control and induce landscape changes but is subject to natural processes and hazards due to severe and extreme ...
Enrico Miccadei, Tommaso Piacentini
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Italian Journal of Planning Practice, 2014 In Italy, recent University reforms, a research quality assessment exercise, and the selection of academics by means of innovative procedures are all accelerating the discussion on the specificity ofresearch on spatial planning and urban design.
Bruno Zanon
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source