Results 141 to 150 of about 1,020,195 (308)
The Role of Knowledge in the prevention of natural hazards and related risks.
Italian Journal of Planning Practice, 2014 Human activities, especially over the last two centuries, have had a huge impact on the environment and the landscape. Mankind is able to control and induce landscape changes but is subject to natural processes and hazards due to severe and extreme ...
Enrico Miccadei, Tommaso Piacentini
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Italian Journal of Planning Practice, 2014 In Italy, recent University reforms, a research quality assessment exercise, and the selection of academics by means of innovative procedures are all accelerating the discussion on the specificity ofresearch on spatial planning and urban design.
Bruno Zanon
doaj
"Prospects for the U.S. and the World -- A Crisis That Conventional Remedies Cannot Resolve" [PDF]
The economic recovery plans currently under consideration by the United States and many other countries seem to be concentrated on the possibility of using expansionary fiscal and monetary policies alone. In a new Strategic Analysis, the Levy Institute's
Dimitri B. Papadimitriou +2 more
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Noncommunicable Disease (NCD) strategic plans in low- and lower-middle income Sub-Saharan Africa: framing and policy response. [PDF]
Glob Health Action, 2020 Boudreaux C +8 more
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Italian Journal of Planning Practice, 2014 The debate on the possibility of transfering the right to build, defined and intended as the development right, does not have a long tradition in Italy. In fact, it is only since the mid 1990s, when Perequazione (equalization) was introduced in practice,
Enzo Falco
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source