Results 61 to 70 of about 106,305 (314)

Strategic Plans, Joint Doctrine and Antipodean Insights [PDF]

open access: yes, 1995
The common view is that doctrine persists over a broader time frame than planning and that the latter draws on the former for context, syntax, even format. In truth the very process of planning shapes new ways of military action.
Young, Thomas-Durell   +1 more
core  

Strategic Takt Planning [PDF]

open access: yesAnnual Conference of the International Group for Lean Construction
Reports on the use of takt tend to focus on applications aimed at so-called operational takt planning. Instead, this paper focuses on strategic takt planning. Strategic- and operational takt planning must go hand in hand. Specifically, strategic takt planning is required upfront in project delivery as it informs prospective contractors what is expected
Tommelein, ID, Emdanat, S
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Strategic Planning in Turkish Local Administrations: How Participatory is it?

open access: yesCurrent Perspectives in Social Sciences
Strategic plans are more participatory, more responsive, more integrated and more empowering when compared to the traditional plans. It has been nearly 20 years since the Financial Management and Control Law in Turkey required public institutions ...
İhsan İkizer
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Administrator's Perceptions of Student Success and its Impact on School and School Board Strategic Plans

open access: yes, 2019
Strategic planning is a contentious term that is used by many but understood by few. The words ‘strategic planning’ can mean a variety of differing purposes, processes, and outcomes.
Mitchell, Alex
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The Bumpy Road to Good Governance and Public Service Delivery : Analysis of the Challenges to Strategic Plans Implementation in Public Organisations in The Gambia

open access: yesPublic Governance, Administration and Finances Law Review
Scholars have long established the connections between strategic plans and service delivery and how lack of dedicated plans to clinically bypass the attendant complexities and intricacies tends to undermine the efficacy of the implementation process ...
Banna Sawaneh, Taiwo A. Olaiya
doaj   +1 more source

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