Results 71 to 80 of about 1,538,190 (269)

The implications of strategic purchasing decisions on the value chain [PDF]

, 1998
Many multinational companies (MNCs) recognise that their ability to become world-class competitors is based on establishing high levels of trust and cooperation with their suppliers, particularly small and medium-sized enterprises (SMEs). This paper presents a fifteen criteria model which describes the purchased package in a partnership relationship ...
McAleer, W, McIvor, R, Mak, KL, Humphreys, PK   +3 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Organising purchasing and (strategic) sourcing: towards a typological theory

International Journal of Technology Intelligence and Planning, 2015
The role of purchasing has changed over the past two to threedecades. The focus is no longer limited to purchasing manufacturing inputs, butalso includes sourcing of innovations from, and even co-developingtechnologies together with, suppliers. Furthermore, purchasing has obtained amuch more mature role in corporate strategy.
Lidegaard, Nina, Boer, Harry; id_orcid 0000-0002-0796-8327, Møller, Morten Munkgaard   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Counter-verification in performance-based financing: key insights from the Côte d’Ivoire experience

Global Health Action
Background Performance-based financing (PBF) is a key health financing reform in many sub-Saharan African countries, with verification being a critical component.
Joël Arthur Kiendrébéogo, Kouadjo San Boris Bediakon, Jean-Pierre Tsafack, Marin Passerat De Silans, Robert Yao Kouakou, Clovis Kouassi Konan, Sosthène Dougrou, Xavier Lannuzel, Serge Mayaka Manitu   +8 more
doaj   +1 more source

Purchasing Organization and Design: A Literature Review [PDF]

This paper presents the results of a comprehensive literature review of the organization of purchasing covering the period from 1967 to 2009. The review provides a structured overview of prior research topics and findings and identifies gaps in the ...
Christoph Glock, Simon Hochrein
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The strategic importance of purchasing in food production companies in the Republic of Serbia [PDF]

Anali Ekonomskog fakulteta u Subotici, 2017
In the contemporary hypercompetitive environment in which the struggle to win market space is becoming increasingly aggressive and dynamic, and where only those companies that have integrated a high level of flexibility, innovation and competitiveness in
Ličina Mile
doaj