Results 51 to 60 of about 85,146 (246)

ARTIFICIAL INTELLIGENCE AFFECTING STRATEGIC STABILITY

International Journal of Advanced Research, 2022
Introduction of artificial intelligence(AI) in the nuclear weapons system exerts the stabilizing as well as destabilizing effect on strategic stability. AI enables informed decision making, development of more survivable delivery vehicle, physical and cyber security of nuclear assets, reduction in possibility of human error, surveillance of compliance ...
openaire   +1 more source

New Technologies & Strategic Stability [PDF]

Daedalus, 2020
A variety of new technologies, ranging from broad enabling technologies to specific weapon systems, may threaten or enhance strategic stability. In this essay, I analyze a technology's potential to significantly affect stability along three axes: the pace of advances in, and diffusion of, this technology; the technology's implications for deterrence ...
openaire   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Entering 2025: U.S.–Russian relations in the estimates and forecasts of American experts

Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика
The Biden administration’s policy toward Russia have plunged U.S.–Russian relations into a deep crisis. The bilateral negotiation process on military and political issues, including disarmament and regional conflicts, has been frozen.
V. I. Batyuk
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

To be continued? Book review of ‘Nuclear arms control in Russian-American strategic relations (2010 — early 2020s)’ by O.M. Aleksandriya and A.G. Savel’ev

Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика
The book under review is a new monograph by O.M. Aleksandriya and A.G. Savel’ev ‘Nuclear arms control in Russian-American strategic relations (2010 — early 2020s)’ published in 2024.
V. I. Mizin
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source