Results 151 to 160 of about 13,409,388 (337)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation

Scientific Reports
Beneficial effects of sodium glucose co-transporter 2 inhibitors (SGLT2is) in cardiovascular diseases have been extensively reported leading to the inclusion of these drugs in the treatment guidelines for heart failure.
Kevin Schmidt, Arne Schmidt, Sonja Groß, Annette Just, Angelika Pfanne, Maximilian Fuchs, Maria Jordan, Elisa Mohr, Andreas Pich, Jan Fiedler, Thomas Thum   +10 more
doaj   +1 more source

Prostaglandin D₂ Synthase: A Novel Player in the Pathological Signaling Mechanism of the Aldosterone–Mineralocorticoid Receptor Pathway in the Heart

Cells
Background: A deregulated aldosterone (Aldo)–mineralocorticoid receptor (MR) pathway is linked to cardiovascular disease (CVD), including hypertension and heart failure.
Ankita Garg, Malte Juchem, Sinje Biss, Carla Nunes Borisch, Julia Leonardy, Christian Bär, Shashi Kumar Gupta, Thomas Thum   +7 more
doaj   +1 more source

The final push strategy to eliminate leprosy as a public health problem: questions and answers

, 2002

openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Increase in mechanical load and pro-fibrotic stimulation leads to fibrotic and hypertrophic remodeling in porcine living myocardial slices

Scientific Reports
Heart failure (HF) is a growing global health concern, driven by factors such as increased mechanical load of the heart muscle tissue. This pathogenic condition is the result of remodeling processes, partially mediated by the cytokine transforming growth
Marco Bentele, Sophie Linke, Susanne Neumüller, Andrea Korte, Anika Gietz, Annette Just, Angelika Stucki-Koch, Angelika Pfanne, Junqing Liu, Jiahao Zhao, Cornelia Schwennen, Christian Homann, Christian Visscher, Michael Pflaum, Bettina Wiegmann, Christian Bär, Natalie Weber, Jan Fiedler, Thomas Thum   +18 more
doaj   +1 more source

Editorial: Water-smart crop farming: a holistic approach to its practice as a climate change adaptation strategy in Sub-Saharan Africa [PDF]

Patricia Amankwaa-Yeboah, Stephen Yeboah, D. Oppong-Sekyere   +2 more
openalex   +1 more source

Developing strategies to commercialise biofortified crops and foods

, 2022
Annette M. Nyangaresi, Valerie M Friesen, Bonnie McClafferty, Charl van der Merwe, Dan Haswell, Byron Reyes, Bho Mudyahoto, Mduduzi N. N. Mbuya   +7 more
openalex   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Does the Use of Metacognitive Strategies Influence Students’ Problem Solving Skills in Physics?

, 2014
Ali. M. C. Shareeja, Abdul Gafoor
openalex   +1 more source