Results 91 to 100 of about 10,984,262 (303)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Big Strategy/Small Strategy [PDF]
Strategic Organization, 2012 My title plays on Rumelt’s (2011) instant classic Good Strategy/Bad Strategy. That book focuses on what works well or otherwise for organizations. Big Strategy/Small Strategy switches the focus to different issues. ‘Small Strategy’ is about financial performance, typically of firms in competitive industries.
openaire +2 more sources
The Need and Requirements to a Strategy Ontology [PDF]
, 2020 The importance of strategy and strategy construct is not a new phenomenon. However as strategy work becomes less tangible, concerns with understanding, describing, and managing strategies develops into an increasingly complex subject. Current strategy
Caine, Jamie, von Rosing, Mark
core
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Donor Advisors and Philanthropic Strategy [PDF]
, 2008 Based on a literature review and interviews, explores how donor advisors shape the philanthropic strategies of the wealthy. Looks at the key activities and elements of effective advising, the need for training, and the potential for ...
Lilli Friedland, Thomas E. Backer
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
An alternative regional strategy [PDF]
, 2004 Regions, this extract suggests, cannot bring about regional inequality without significant national level action. The key, it is claimed, is a ‘national commitment to decentre the economy’.
Amin, Ash, Massey, Doreen, Thrift, Nigel
core