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Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
Women's Economic Empowerment Strategy [PDF]
In this document the William and Flora Hewlett Foundation outlines its strategy and motivation for supporting a focused agenda on women's economic ...
core
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria+3 more
wiley +1 more source
China's geoeconomic strategy: China’s strategy towards the financial crisis and economic reform [PDF]
China’s pragmatic attitude towards its own 30 years of reform can be used to similarly characterise its attitude toward the global fi nancial crisis of 2008 and the resultant push for further economic reforms.
Yueh, Linda Y.
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen+2 more
wiley +1 more source
Strategi merupakan rencana-rencana untuk mencapai tujuan organisasi. Strategi masing-masing umumnya berbeda di antara organisasi yang satu dan lainnya. Sistem pengendalian manajemen merupakan alat untuk mengimplementasikan strategi. Pengendalian harus menyesuaikan dengan kebutuhan strategi organisasi.
openaire +1 more source
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield+3 more
wiley +1 more source
It is difficult to think of a single word to describe the White Paper Modernising NHS Dentistry — Implementing the NHS Plan that was launched on 19th September. Words that came into my mind included 'official', 'innovative', 'comprehensive', 'clear', 'slick' and 'clever'.
openaire +3 more sources
From Strategy to Practice [PDF]
{Excerpt} Strategic reversals are quite commonly failures of execution. In many cases, a strategy is abandoned out of impatience or because of pressure for an instant payoff before it has had a chance to take root and yield results. Or its focal point is
Serrat, Olivier
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