Results 101 to 110 of about 18,618,095 (348)
Global Challenges, 2018 Scientifically‐derived insights are often held as requirements for defensible policy choices. Scientific advisory committees (SACs) figure prominently in this landscape, often with the promise of bringing scientific evidence to decision‐makers.
Steven J. Hoffman +4 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
IET OptoelectronicsThe authors demonstrate the use of highly temperature insensitive dense wavelength division multiplexing filters combined with optical reflectors and optical time domain reflectometry to uniquely identify specific optical fibres beyond the optical ...
Stephanie R. Bally +3 more
doaj +1 more source
Review of spent nuclear fuel management in different developed countries
Mechanical Engineering JournalSpent nuclear fuel (spent fuel), which is used nuclear fuel that has been exposed to radiation usually produced by nuclear reactors in nuclear power plants, is an inevitable product from the development of nuclear energy.
Lei SHI, Yihan WANG, Na MA, Hongjun LIU
doaj +1 more source
Modeling the implementation of NDCs and the scenarios below 2°C for the Belt and Road countries
Ecosystem Health and Sustainability, 2020 In order to understand better on medium-and long-term climate change issues in international cooperation of the Belt and Road Initiative (BRI), this paper is meant to assess the implementation of National Determined Contributions (NDCs) of the BRI ...
Chai Qimin, Fu Sha, Wen Xinyuan
doaj +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source