Results 121 to 130 of about 5,554,709 (315)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

National Rice Development Strategy 2008-2018

, 2008
This strategy sets the vision, mission, objectives and strategies that Ministry will pursue in ten years with the aim of facilitating growth and development of the rice sub-sector. It will form the basis of which work plans will be formulated at national

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An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

National Climate Change Response Strategy 2010

, 2010
In response to the challenges and opportunities posed by climate change, Kenya has developed this National Climate Change Response Strategy. The vision of the Strategy is for a prosperous and climate change resilient Kenya.

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Research on the impact of green finance on regional carbon emission reduction and its role mechanisms

Scientific Reports
As a crucial instrument, green finance policy facilitates the transition toward a green and low-carbon regional economic structure, which is essential for realizing the target of “double carbon” and the harmonious coexistence of nature and humans ...
Huiyun Li, Zongbao Yu, Gang Chen, Yingjun Nie   +3 more
doaj   +1 more source

Long-term probabilistic forecasts of activity mitigation in English hospitals: a national elicitation exercise providing an outside view based on judgements of experts in support of the New Hospital Programme

BMJ Open
Objectives The planning process for a new hospital relies on assumptions about future levels of demand. Typically, such assumptions are characterised by point estimates, the flaw-of-averages, base-rate neglect and overoptimism from an inside view.
Mohammed A Mohammed, Steven Wyatt, Thomas Jemmett, Josh Cook, Jake Parsons, Chris Beeley, Peter Spilsbury   +6 more
doaj   +1 more source

A balancing strategy

Journal of Combinatorial Theory, Series A, 1985
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Nyeri County Fiscal Strategy Paper 2015

, 2015
The preparation of the CFSP, 2015 is a collaborative effort of the county departments with overall coordination by the Finance and Economic Planning department.

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