Results 141 to 150 of about 5,554,709 (315)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Kenya Youth Agribusiness Strategy 2018-2022
, 2018 The MoALF in consultation with the County Governments and development partners have developed the Strategy with a view to increasing meaning and sustainable youth participation in the agricultural sector.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
National Agribusiness Strategy 2012
, 2012 In Kenya, agriculture contributes about 25 percent of gross domestic product (GDP) and provides a livelihood to three-quarters of the population. Food production plays an important part in maintaining the country’s food security, while the industrial ...
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Meru County Covid 19 Socio-Economic Re-engineering Recovery Strategy 2020/2021-2022-2023
, 2020 This County COVID-19 Re-Engineering and Recovery Strategy 2020/21-2022/23 embeds the principles of response, recovery and thriving. The counties will continue to respond to the crisis while dealing with the immediate effects of the pandemic to contain it,
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Kenya National Energy Efficiency and Conservation Strategy 2020
, 2020 Energy Efficiency and Conservation is one of the key pillars of sustainable development in Kenya. The government has placed it as one of the priority areas of improvement in its efforts to enhance the quality of life of its citizens.
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The Strategy of the Objective: A Hermeneutic Approach to Strategy
Strategic literature has offered innumerable methods for achieving objectives, yet it has largely neglected the objective itself. Although objectives are commonly represented as a desired end state, there exists a relative will on the part of the opposing actor that resists that outcome and therefore also forms part of the final conditions.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source