Results 141 to 150 of about 17,506,218 (372)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Analgesic strategies

open access: yesSouth African Family Practice, 2014
No abstract available.
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Developing a protocol on antimicrobial resistance through WHO’s pandemic treaty will protect lives in future pandemics

open access: yesGlobalization and Health
Addressing antimicrobial resistance (AMR) through the pandemic treaty is a crucial aspect of pandemic prevention, preparedness, and response. At the moment, AMR-related provisions in the draft text do not go far enough and will likely lead countries to ...
Arne Ruckert   +2 more
doaj   +1 more source

The rush to the Arctic: Geopolitical linkages and challenges for Indo-Pacific regional stability

open access: yesInternational Review of Social Sciences Research
This study aims to evaluate how great power competition in the Arctic, driven by new maritime routes emerging from melting sea ice due to climate change, significantly reduces shipping distances between Europe and Asia and impacts the dynamics of the ...
Maria Chris Lievonne   +2 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

The future of regulatory filings: digitalization

open access: yesAAPS Open
The biopharmaceutical industry, while advancing rapidly in drug development, has lagged in the digitalization of regulatory submissions, leading to inefficiencies, delays, and increased administrative burdens.
Kabir Ahluwalia   +5 more
doaj   +1 more source

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