Results 151 to 160 of about 4,606,527 (317)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Instructed learning strategy use eliminates negative reactivity of immediate judgments of learning. [PDF]

Psychon Bull Rev
Ingendahl F, Undorf M.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Approaches for Generating and Evaluating Product Positioning Strategy

, 2013
Oghojafor Ben Akpoyomare, Ladipo Patrick Kunle Adeosun, Rahim Ajao Ganiyu   +2 more
openalex   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Modeling the clinical and economic impact of universal varicella vaccination in Belgium with dynamic population. [PDF]

PLOS Glob Public Health
Lang JC, Nachbar RB, Xausa I, Bento-Abreu A, Merckx B, Pawaskar M.   +5 more
europepmc   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Liberal Versus Restrictive Blood Transfusion Strategies in Neurocritical Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Crit Care Res Pract
Shaukat A, Zahoor MA, Khan K, Khan AS, Saleem R, Ariyasiri A, Aziz Jameel SA, Afridi S, Salman SJ, Naeem N, Ashraf M, Chaudhry AR, Ahmad Z, Larik MO, Hasanain M, Anjum MU, Akilimali A.   +16 more
europepmc   +1 more source

Disrupting the Hsp90–Cdc37 axis: a selective strategy for targeting oncogenic kinases in cancer

Emadeldin M. Kamel, Mohamed A. M. Ali, Ahmed A. Allam, Noha Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
openalex   +2 more sources

Evaluation of Three Forest-Based Bioenergy Development Strategies in the Inland Northwest, United States [PDF]

, 2018
Darin Saul, Soren Newman, Steven Peterson, Eli Kosse, Ryan Jacobson, Robert Keefe, Stephen Devadoss, Tammy Laninga, Jill Moroney   +8 more
openalex   +1 more source