Results 71 to 80 of about 17,506,218 (372)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Decarbonizing surgical care: a qualitative systematic review guided by the Congruence Model

BMC Health Services Research
Background The healthcare sector must navigate the challenge of caring for individuals affected by climate change while being a significant emitter of carbon emissions. This study focuses on direct sources of carbon emissions from hospital surgical care,
Leonard Kloevekorn, Oskar Roemeling, Amal Fakha, Eveline Hage, Edin Smailhodzic   +4 more
doaj   +1 more source

The Analysis of Premium Strategy and Vehicle Claims in Increasing Revenues of PT Asuransi Sinar Mas Tangerang [PDF]

, 2018
This research conducted  to determine the premium strategy and insurance claims at PT. Asuransi Sinar Mas Branch of Tangerang period 2005-2015 using SWOT analysis method. Through SWOT analysis can be known the premium strategy that can be applied by
Anggraini, A. (Anggun)
core  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Towards a Systematic Understanding of How to Institutionally Design Scientific Advisory Committees: A Conceptual Framework and Introduction to a Special Journal Issue

Global Challenges, 2018
Scientifically‐derived insights are often held as requirements for defensible policy choices. Scientific advisory committees (SACs) figure prominently in this landscape, often with the promise of bringing scientific evidence to decision‐makers.
Steven J. Hoffman, Trygve Ottersen, Ali Tejpar, Prativa Baral, Patrick Fafard   +4 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

The Split-Apply-Combine Strategy for Data Analysis

, 2011
Many data analysis problems involve the application of a split-apply-combine strategy, where you break up a big problem into manageable pieces, operate on each piece independently and then put all the pieces back together.
H. Wickham
semanticscholar   +1 more source

Pull Strategy: a Marketing Strategy Public Relations to Maintain Customer Loyalty [PDF]

, 2018
Customer loyalty is most important asset for every company. Customer loyalty gives company many benefits such as repeat purchase and recommendation to third party.
purwanti, A. (angel)
core