Results 61 to 70 of about 5,151,198 (278)

Formulating RALA/Au nanocomplexes to enhance nanoparticle internalisation efficiency, sensitising prostate tumour models to radiation treatment

Journal of Nanobiotechnology, 2021
Background Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency.
Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy, Jonathan A. Coulter   +6 more
doaj   +1 more source

Opportunities and challenges for enhancing preconception health in primary care: qualitative study with women from ethnically diverse communities

BMJ Open, 2013
Objective  There is a growing interest in developing and offering more systematic preconception healthcare. However, it is unclear how this might be regarded by ethnically diverse communities at higher risk of poor maternal and child health outcomes.
Joe Kai, Nadeem Qureshi, Helena Tuomainen, Laura Cross-Bardell, Mandeep Bhoday   +4 more
doaj   +1 more source

A Systematic Approach to Review of in vitro Methods in Brain Tumour Research (SAToRI-BTR): Development of a Preliminary Checklist for Evaluating Quality and Human Relevance

Frontiers in Bioengineering and Biotechnology, 2020
BackgroundA wide range of human in vitro methods have been developed and there is considerable interest in the potential of these studies to address questions related to clinical (human) use of drugs, and the pathobiology of tumours.
Mike Bracher, Geoffrey J. Pilkington, C. Oliver Hanemann, Karen Pilkington   +3 more
doaj   +1 more source

Stratified Care vs Step Care Strategies for Migraine [PDF]

JAMA, 2000
Various guidelines recommend different strategies for selecting and sequencing acute treatments for migraine. In step care, treatment is escalated after first-line medications fail. In stratified care, initial treatment is based on measurement of the severity of illness or other factors.
Andrew Stone, Miguel J. A. Láinez, J. Sawyer, Walter F. Stewart, Richard B. Lipton   +4 more
openaire   +3 more sources

Patients’ and physiotherapists’ perspectives on implementing a tailored stratified treatment approach for low back pain in Nigeria: a qualitative study

BMJ Open, 2022
Background Stratified care has the potential to be efficient in addressing the physical and psychosocial components of low back pain (LBP) and optimise treatment outcomes essential in low-income countries.
Kay Stevenson, Mishael Adje, Jost Steinhäuser, Chidozie Emmanuel Mbada, Sven Karstens   +4 more
doaj   +1 more source

Stratified primary care for adults with musculoskeletal pain: the STarT MSK research programme including RCTs

Programme Grants for Applied Research, 2023
Background Usual primary care for patients with musculoskeletal pain varies widely and treatment outcomes are suboptimal. Stratified care involves targeting treatments according to patient subgroups, in the hope of maximising treatment benefit and ...
Foster Nadine E, Dunn Kate M, Protheroe Joanne, Hill Jonathan C, Lewis Martyn, Saunders Benjamin, Jowett Sue, Hennings Susie, Campbell Paul, Bromley Kieran, Bartlam Bernadette, Babatunde Opeyemi, Wathall Simon, Oppong Raymond, Kigozi Jesse, Chudyk Adrian   +15 more
doaj   +1 more source

The central role of provider training in implementing resource‐stratified guidelines for palliative care in low‐income and middle‐income countries: Lessons from the Jamaica Cancer Care and Research Institute in the Caribbean and Universidad Católica in Latin America

Cancer, 2020
Individuals in low‐income and middle‐income countries (LMICs) account for approximately two‐thirds of cancer deaths worldwide, and the vast majority of these deaths occur without access to essential palliative care (PC).
Mark Stoltenberg, D. Spence, B. Daubman, N. Greaves, R. Edwards, Brittany Bromfield, P. Perez-Cruz, E. Krakauer, M. Argentieri, Alexandra E. Shields   +9 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source