Results 91 to 100 of about 261,494 (266)

Effect of Stratified Flow on the Vibration of Anchor Cables in a Submerged Floating Tunnel

open access: yesJournal of Marine Science and Engineering
This study investigates the vertical-type submerged floating tunnel with anchor cables. Based on the characteristics of the anchor cables, the anchor cables are simplified as a nonlinear beam model with hinged ends. Disregarding the axial displacement of
Jiaming Xiong   +3 more
doaj   +1 more source

Flow patterns and critical criteria of thermally stratified shear flow in braided rivers

open access: yesWater Science and Engineering, 2017
Flow characteristics of thermally stratified shear flow in braided rivers are particularly complicated and poorly understood. In this study, a series of typical flow patterns was examined and their critical criteria were determined.
Li Gu   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Turbulent stratified open channel flow with solar heating up to Pr=7 using Direct Numerical Simulation

open access: yes
This paper investigates the turbulent structure of stratified open-channel flow subjected to a radiative volumetric heat source modelled by the Beer–Lambert law, for Prandtl numbers ( ) varying from 0.07 to .
MacDonald, Michael   +2 more
core   +1 more source

Large-scale structures in a stratified open channel flow

open access: yesMATEC Web of Conferences, 2017
We present the results of direct numerical simulation of stably stratified open channel flow. The simulation was conducted in a frame of reference moving with the mean flow.
Borynyak Konstantin, Hrebtov Michael
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Blood flow in microvascular networks

open access: yes, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
Mansour, MH   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Analytical and CFD Modeling of the Fluid Flow in an Eccentric-Tube Centrifugal Oil Pump for Hermetic Compressors

open access: yes, 2012
A model is presented for calculating the volume flow rate in an eccentric-tube centrifugal oil pump for reciprocating compressors. The oil pump assembly consists of a pick-up tube with an inclined inlet that is mounted off-center with the crankshaft ...
Barbosa Jr., Jader   +2 more
core  

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