Results 91 to 100 of about 26,266 (260)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dissipative Nonlinear Schrödinger Equation for Envelope Solitary Rossby Waves with Dissipation Effect in Stratified Fluids and Its Solution

Abstract and Applied Analysis, 2014
We solve the so-called dissipative nonlinear Schrödinger equation by means of multiple scales analysis and perturbation method to describe envelope solitary Rossby waves with dissipation effect in stratified fluids.
Yunlong Shi, Baoshu Yin, Hongwei Yang, Dezhou Yang, Zhenhua Xu   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Richtmyer-Meshkov instabilities in stratified fluids [PDF]

, 1983
We present an analytic theory of Richtmyer-Meshkov instabilities in an arbitrary number N of stratified fluids subjected to a shock. Following our earlier work on Rayleigh-Taylor instabilities, the theory assumes incompressible flow in which a shock is ...
Mikaelian, K.O.
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Nonlinear squeezing flow of stratified fluids: A comprehensive study on convective conditions and probable errors

International Journal of Thermofluids
A thorough understanding of magnetohydrodynamic (MHD) squeezing fluid flow in non-Darcian media is essential for advancing a wide range of engineering applications, including cooling systems, polymer processing, and biomedical devices.
Anum Shafiq, Tabassum Naz Sindhu, Muhammad Ahmad Iqbal, Tahani A. Abushal   +3 more
doaj   +1 more source

Progressive waves of permanent form in continuously stratified fluids

, 1974
A theory for internal progressive waves of permanent form in any continuously stratified fluid is presented, and a calculation for the flow and the wave velocity is carried out for an exponential stratified fluid.
Yih, Chia‐shun, Chia-Shun Yih
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The combined effects of anisotropic porous medium and stably stratified fluid on free convective flow through an annulus

Journal of Taibah University for Science, 2018
This paper documents the semi-analytical results for transient natural convection fluid flow between two concentric vertical cylinders of infinite lengths in the presence of anisotropic porous medium and stratified fluid.
Basant K. Jha, Muhammad K. Musa
doaj   +1 more source

Experimental Characterisation of Swirl Stabilized Annular Stratified Flames [PDF]

, 2007
A burner for investigating lean stratified premixed flames propagating in intense isotropic turbulence has been developed. Lean pre-mixtures of methane at different equivalence ratios are divided between two concentric co-flows to obtain annular ...
Bonaldo, Alessio
core