Results 101 to 110 of about 26,266 (260)

Spectral and scattering theory in perturbed stratified fluids. II. Transmission problems and exterior domains

, 1986
The spectral and scattering theory of the acoustic propagator in perturbed stratified fluids is studied in the cases of transmission problems and of exterior ...
Weder, Ricardo
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Dynamical analyses and dispersive soliton solutions to the nonlinear fractional model in stratified fluids

Open Physics
This study explores the bifurcation analysis, sensitivity analysis (SA), stability analysis, and exact solitonic wave profiles for the time-fractional Benjamin–Ono (BO) equation, which models internal waves in stratified fluids, especially where ...
Bilal Muhammad, Rehman Shafqat Ur, Younas Usman, Mohammad Alsharef, Rezapour Shahram, Inc Mustafa   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Variable thermal conductivity and mass diffusivity effects in a free convective flow of doubly stratified non-darcian porous medium over a vertical plate

International Journal of Applied Mechanics and Engineering
The research in this article is carried out to study incompressible and unsteady free convective flow on a semi-infinite isothermal vertical plate in a doubly stratified non-Darcian porous media with variable mass diffusivity and variable thermal ...
Suganthi R.K, Bapuji Pullepu, supriya P, Shanmugapriya M, Pop I   +4 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Vortex Rings in Rotating and Stratified Fluids

The traveling distances of a single vortex ring in rotating and stably stratified fluids have been measured by means of the method of flow visualization.
Yamashita, Susumu, Honji, Hiroyuki, 本地, 弘之, ホンジ, ヒロユキ, 山下, 晋, ヤマシタ, ススム   +5 more
core  

Magnetohydrodynamic waves in structured atmospheres

, 2012
The effect of structuring, in the form of magnetic or density inhomogeneities, on the magnetohydrodynamic (mhd) waves of an infinite plasma is investigated.
Edwin, Patricia Mary
core