Results 101 to 110 of about 26,366,925 (292)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
High-Performance Telescope System Design for Space-Based Gravitational Waves Detection
SensorsSpace-based gravitational wave (GW) detection employs the Michelson interferometry principle to construct ultra-long baseline laser interferometers in space for detecting GW signals with a frequency band of 10−4–1 Hz.
Huiru Ji +8 more
doaj +1 more source
, 2016 An experimental installation using a proto of optical antenna telescope with diameter 150 mm, field of view ±0.17 ° and receive wavelength 974 nm has been built to measure the forward scattering, and the result shows that there are two energy ...
Xie, Pei-Yue +6 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Efficient stray light characterisation: a white light interferometry-based method
, 2022 Stray light is light that reaches the detector that is coming from sources other than the intended observed scene and is one of the main limiting factors for the performance of Earth Observation Space Optical Instruments. It often sets a working limit on
Snel, R.C. +6 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Stray-light correction in 2D spectroscopy
, 2013 Context. In solar physics, spectropolarimeters based on Fabry-Pérot interferometers are commonly used for high spatial resolution observations. In the data pipeline, corrections for scattered light may be performed on each narrow band
M. Franz, R. Schlichenmaier
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source