Results 121 to 130 of about 26,366,925 (292)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Design and construction of a light source setup for stray light measurements in array spectrometers [PDF]
, 2018 In this master thesis the construction of a high radiance light source for the measurement of stray light in imaging spectrometers is ...
Kretz, Malte
core
Stray Light Measurement for Point Source Transmittance of Space Optical Systems
, 2016 The increased sensitivity of space-based sensors has imposed greater stray light performance goals on telescope design. To meet the demand, a stray light test station for measuring point source transmission (PST) has been built with a lower threshold ...
Xu, Liang +6 more
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Stray voltage symptoms common in dairy cattle eliminated by on-farm neutral isolation [PDF]
, 2000 Plan BDairy farmers with stray voltage symptoms in their cattle often spend thousands of dollars to do neutral isolation, which isolates the primary neutral of the electricity provider from the farm neutral to suppress stray voltage from off-farm sources
Nackers, Martin
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Fiber-based Stray Light Suppression in Spectrometers
, 2017 Stray light is known as strong interference in spectroscopic measurements. With the creation of a novel kind of customized fibers, manufactured by the fiber optics group in Jena, Germany, a general experimental solution to this problem is possible.
Gong, Miaoxin
core
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source