Results 71 to 80 of about 4,019,827 (271)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Literature survey for suppression of scattered light in large space telescopes [PDF]

, 1973
A literature survey is presented of articles dealing with all aspects of predicting, measuring, and controlling unwanted scattered (stray) light. The survey is divided into four broad classifications: (1) existing baffle/telescope designs; (2) computer ...
Fannin, B. B., Tifft, W. G.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study on Stray Light Testing and Suppression Techniques for Large-Field of View Multispectral Space Optical Systems

IEEE Access
To evaluate the ability of space optical systems to suppress off-axis stray light, this paper proposes a stray light testing method for large-field of view, multispectral spatial optical systems based on point source transmittance (PST).
Yi Lu, Xiping Xu, Ning Zhang, Yaowen Lv, Liang Xu   +4 more
doaj   +1 more source

Stray Light Suppression of Imaging Spectrometers with Convex Gratings

Journal of Physics: Conference Series
Abstract The imaging spectrometer with a convex grating as the core dispersion element has the advantages of relatively large aperture, high imaging quality and compact structure. In order to decrease the effect of stray light on image quality of imaging spectrometers with convex gratings, analyzed and corresponding suppression method ...
Yang Li, Shengbo Mu, Haoyang Li, Tingcheng Zhang, Ting Tan, Yue Ma   +5 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Observational Technological Innovations and Future Development of the Lijiang Coronagraph

Instruments
As a core ground-based coronal observation facility in the low-latitude and high-altitude regions of China, the Lijiang Coronagraph takes advantage of the natural endowments of the Lijiang Astronomical Observation Station, such as an altitude of 3200 m ...
Xuefei Zhang, Yu Liu, Tengfei Song, Mingyu Zhao, Xiaobo Li, Mingzhe Sun, Feiyang Sha, Xiande Liu   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Feasibility study of SOA-based noise suppression for spectral amplitude coded OCDMA [PDF]

, 2007
We investigate the benefits of employing a saturated SOA to reduce optical noise in an incoherent light OCDMA system. In the context of spectrum-slicing, SOA-based noise suppression has shown significant potential for enhancing the signal quality of ...
Horak, P., Anoma D. McCoy, Morten Ibsen, David J. Richardson, Thomsen, B.C., Benn C. Thomsen, McCoy, A.D., Ibsen, M., Peter Horak, Richardson, D.J.   +9 more
core   +2 more sources